Detoxification treatment in Gynecology using a modified molded sorbent

Area of Science:

• Obstetrics and Gynecology
• Infectious Diseases
• Medical Device Technology

Background:

• Postpartum endometritis is a frequent complication following cesarean section.
• It can lead to severe consequences, including hysterectomy and infertility.
• Antibiotic resistance complicates treatment of postpartum infections.

Purpose of the Study:

• To evaluate the efficacy of a novel intrauterine sorbent therapy for postpartum endometritis.
• To compare outcomes of combined antibiotic and sorbent treatment versus antibiotics alone.
• To assess the impact on inflammatory markers, microbial load, and uterine recovery.

Main Methods:

• A retrospective, controlled study involving 124 patients with postpartum endometritis post-cesarean section.
• The study group (n=63) received antibiotics plus a modified sorbent containing polyvinylpyrrolidone (FSMP) for 5 days.
• The control group (n=61) received antibiotics only.

Main Results:

• The sorbent group showed a faster decrease in neutrophils and significantly lower levels of IL-1β and TNFα.
• Reduced uterine volume and cavity size (M-echo) were observed in the sorbent group.
• Hysterectomy frequency decreased by 14.4 times in the group receiving the sorbent therapy.

Conclusions:

• Intrauterine application of the modified sorbent, alongside antibiotics, effectively reduces inflammation and infection in postpartum endometritis.
• This combined therapy promotes faster uterine involution and significantly lowers the need for hysterectomy.
• The novel sorbent represents a promising adjunctive treatment for managing postpartum endometritis, especially with rising antibiotic resistance.