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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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DIABETIC NEPHROPATHY: NOVELTY ABOUT THE DIABETIC NEPHROPATHY TREATMENT IN CHILDREN

Ievgeniia A Burlaka1, Inga O Mityuryayeva1, Tetiana A Shevchenko1

  • 1BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|May 25, 2023
PubMed

Insights

Diabetic nephropathy (DN) in children presents a significant healthcare challenge, causing irreversible kidney damage and cardiovascular complications. Effective treatment requires a complex, individualized approach, with ongoing research for novel neproprotective medications.

Area of Science:

  • Pediatric Nephrology
  • Diabetology
  • Cardiovascular Medicine

Background:

  • Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in children.
  • DN progression is associated with severe cardiovascular complications and increased mortality.
  • Current treatment strategies for pediatric DN are complex and require individualized care.

Approach:

  • This review analyzes current and emerging data on DN treatment in pediatric patients.
  • It examines the role of renoprotective and antihypertensive therapies.
  • The paper discusses advancements in medications that complement renin-angiotensin-aldosterone system (RAAS) blockade.

Key Points:

  • DN poses a major global health challenge, contributing to irreversible kidney damage.
  • Effective DN management necessitates a multifaceted approach, including renoprotection and blood pressure control.
  • Newer medications offer enhanced benefits when combined with RAAS blockade.

Conclusions:

  • DN treatment in children is a complex clinical issue demanding personalized strategies.
  • While current treatments offer benefits, further research into neproprotective agents is crucial for early DN correction in pediatric populations.
  • Continued investigation into novel therapies is essential to mitigate the long-term consequences of DN in children.
Abstract

Keywords:
kidney damagecorrectiondiabetic nephropathytreatment

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