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Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
Published on: March 14, 2020
The dynamic microenvironment associated with metastatic bone disease: Current concepts
Rahul Bhale1, Paramita Ghosh1, Raminta Theriault1
1Department of Orthopaedic Surgery, University of California, Sacramento, California, USA.
Abstract:
Patients with bone metastases may experience debilitating pain, neurological conditions, increased risk of pathological fractures, and death. A deeper understanding of the bone microenvironment, the molecular biology of cancer types prone to metastasis, and how bone physiology promotes cancer growth, may help to uncover targeted treatment options. The purpose of this paper is to outline the current concepts relevant to topics including bone remodeling, angiogenesis, and immunomodulation as it relates to metastatic bone disease.
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