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Updated: Jul 29, 2025

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Palladium-Catalyzed Thiocarbonylative Synthesis of α,β-Unsaturated Thioesters Using S-Aryl Thioformates as the
Zekai Shen1, Yong-Wang Huo1, Xinxin Qi1
1Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, People's Republic of China.
Abstract:
A palladium-catalyzed thiocarbonylation reaction for the synthesis of α,β-unsaturated thioesters from vinyl triflates with S-aryl thioformates as the thioester sources has been developed. The reaction proceeded smoothly at low temperature, and a variety of α,β-unsaturated thioesters were produced in moderate to high yields with very good functional group tolerance. This protocol features mild reaction conditions, good substrate scope, and avoids the use of toxic CO gas or odorous thiols, which made it a worthy addition to α,β-unsaturated thioester synthesis via a thioester transfer process.
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