Risk of Adverse Outcomes Associated With Cardiac Sarcoidosis Diagnostic Schemes

Area of Science:

• Cardiology
• Immunology
• Internal Medicine

Background:

• Multiple diagnostic schemes for cardiac sarcoidosis (CS) exist.
• Evaluating these schemes' association with clinical outcomes is crucial for patient management.

Purpose of the Study:

• To assess the correlation between different CS diagnostic criteria and adverse clinical outcomes.
• Compare the predictive value of 1993, 2006, and 2017 Japanese criteria and the 2014 Heart Rhythm Society criteria.

Main Methods:

• Utilized data from the international Cardiac Sarcoidosis Consortium registry.
• Defined adverse outcomes as all-cause mortality, LVAD, heart transplant, or appropriate ICD therapy.
• Employed logistic regression to analyze the association between diagnostic schemes and outcomes.

Main Results:

• Patients meeting the 1993 (35.2%) and 2006 (37.2%) Japanese criteria showed significantly higher odds of adverse events compared to those who did not.
• No statistically significant association was found between adverse events and meeting the 2014 Heart Rhythm Society or 2017 Japanese criteria.
• The 1993 criteria (OR 2.00) and 2006 criteria (OR 2.54) were independently associated with increased adverse outcomes.

Conclusions:

• The 1993 and 2006 Japanese criteria for CS are associated with a higher likelihood of adverse clinical outcomes.
• Further prospective research and development of novel risk models are necessary for managing CS.