Related Experiment Video
Updated: Jul 29, 2025

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
Riding up the escaLEC-TOR for valvular health
1Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, USA.
Abstract:
Endothelial-lined valves assure unidirectional flow in the lymphatic system. In this issue, Saygili Demir et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202207049) demonstrate how continuous repair of these valves occur, beginning with mTOR-activated cell replication in valve sinuses, and followed by cell migration to cover the valve surface.
Related Concept Videos
Heart Valves
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Mitral Valve Prolapse II: Assessment and Management
Mitral Stenosis IV: Nursing Management
Mitral Regurgitation I: Introduction
Mitral Stenosis I: Introduction
Mitral Valve Prolapse I: Introduction

