A multi-omics perspective of CAR T cell therapy

Area of Science:

• Immunology
• Biotechnology
• Genomics

Background:

• Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment.
• Understanding the molecular mechanisms underlying CAR T cell efficacy and toxicity is crucial.
• Omics technologies provide a comprehensive view of biological systems.

Purpose of the Study:

• To review the application of multidimensional omics technologies in CAR T cell research.
• To highlight the potential of omics data in identifying tumor-specific antigens.
• To discuss the molecular characteristics associated with anti-tumor effects and toxicities of CAR T cells.

Main Methods:

• Review of recent literature on omics technologies applied to CAR T cell therapy.
• Discussion of genomics, epigenomics, transcriptomics, T cell receptor-repertorie profiling, proteomics, metabolomics, and microbiomics.
• Analysis of how these technologies contribute to understanding CAR T cell function.

Main Results:

• Omics technologies have yielded significant insights into CAR T cell therapy.
• These technologies can identify tumor-specific antigens and biomarkers.
• Molecular characteristics linked to therapeutic effects and adverse events are being elucidated.

Conclusions:

• Multidimensional omics profiling is essential for advancing CAR T cell therapy.
• Integrating various omics data can optimize CAR T cell design and application.
• Further research using omics approaches will improve treatment outcomes and patient safety.