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Increased expression of cell adhesion molecules in myofasciitis
Xue Ma1,2, Huajie Gao2, Li Xu2
1Department of Neurology, Air Force Medical University Tangdu Hospital, Xi'an, China.
Frontiers in Neurology
|May 25, 2023
Summary
Inflammatory cell infiltration in myofasciitis is linked to increased cell adhesion molecules (CAMs), suggesting endothelial activation. This finding highlights CAMs as potential therapeutic targets for treating myofasciitis.
Area of Science:
- Immunology
- Pathology
- Molecular Biology
Background:
- Myofasciitis involves inflammatory cell infiltration into fascia.
- Endothelial activation is crucial in inflammatory responses.
- Cellular adhesion molecule (CAM) expression in myofasciitis remains uninvestigated.
Purpose of the Study:
- To investigate the expression of CAMs in myofasciitis.
- To determine if CAMs are upregulated in affected tissues.
- To explore the role of endothelial activation in myofasciitis pathogenesis.
Main Methods:
- Clinical data, MRI, and muscle pathology were collected from five myofasciitis patients.
- Immunohistochemical (IHC) staining and Western blot (WB) were performed on muscle biopsies.
- Samples from patients were compared to those from healthy controls.
Main Results:
- Four patients exhibited elevated serum pro-inflammatory cytokines (IL-6, TNF-α, IL-2R).
- IHC and WB revealed significantly increased CAM expression in muscle and fascia tissues of patients.
- Upregulated CAMs were observed in blood vessels and inflammatory cells within the perimysium.
Conclusions:
- Increased CAMs in myofasciitis indicate endothelial activation.
- CAMs represent potential therapeutic targets for myofasciitis treatment.
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