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Cefiderocol for Stenotrophomonas maltophilia prosthetic joint infection: a case report

MaKenzie M Chambers1, Christina J Gutowski1,2, Katherine Doktor1,3

  • 1Cooper Medical School, Rowan University, Camden, NJ, USA.

Therapeutic Advances in Infectious Disease
|May 25, 2023
PubMed

Insights

Stenotrophonomas maltophilia periprosthetic joint infections are challenging to treat. A combination of cefiderocol and trimethoprim-sulfamethoxazole successfully treated a case after debridement and implant retention.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Orthopedic Surgery

Background:

  • Stenotrophonomas maltophilia infections pose treatment challenges due to biofilm formation and antibiotic resistance.
  • Periprosthetic joint infections (PJIs) are serious complications requiring effective antimicrobial strategies.

Observation:

  • A patient presented with a Stenotrophonomas maltophilia-associated periprosthetic joint infection.
  • The infection was refractory to standard antibiotic regimens.

Findings:

  • Successful treatment was achieved using a combination therapy of cefiderocol and trimethoprim-sulfamethoxazole.
  • The therapeutic approach involved debridement and implant retention.

Implications:

  • Cefiderocol, a novel agent, shows promise in treating complex S. maltophilia infections.
  • Combination therapy may be a viable strategy for managing PJI caused by multidrug-resistant organisms.
  • This case highlights a potential treatment pathway for challenging Gram-negative bacterial infections in orthopedic settings.
Keywords:
Stenotrophomonas maltophiliacase reportcefiderocolprosthetic joint infection

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