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Updated: Jul 29, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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One-year clinical experience on the use of Nintedanib in systemic sclerosis

Luca Magnani1, Amelia Spinella2, Sofia Testoni1,2

  • 1Rheumatology Unit AUSL-IRCCS of Reggio Emilia Reggio Emilia Italy.

Respirology Case Reports
|May 25, 2023
PubMed

We reviewed 11 patients with systemic sclerosis-related ILD who were referred to our Scleroderma Unit from January 2020 to January 2021 and started Nintedanib. Non-specific interstitial pneumonia (NSIP) was prevalent (45%), usual interstitial pneumonia (UIP) and UIP/NSIP pattern were both 27%. Only one patient had a history of smoking. Eight patients were on mycophenolate mofetil (MMF), eight were treated with corticosteroids (mean dose 5 mg/day of Prednisone or equivalent), and three were on Rituximab. The mean modified British Council Medical Questionnaire (mmRC) decreased from 3 to 2.5. Two patients had to reduce their daily dose to 200 mg/day for severe diarrhoea. Nintedanib was generally well tolerated.

Keywords:
autoimmunityfibrosisinterstitial lung diseaserare diseasesystemic sclerosis

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