Related Experiment Video

Updated: Jul 29, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

489

Modifications of noncoding RNAs in cancer and their therapeutic implications

Le Zhang1, Xiaonan Xu2, Xiulan Su3

  • 1Center for Reproductive Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia, China.

Cellular Signalling
|May 25, 2023
PubMed

Insights

Over 150 RNA modifications impact biological functions and disease, particularly cancer. This review highlights ncRNA modifications

Area of Science:

  • Biochemistry and Molecular Biology
  • Epigenetics
  • Cancer Research

Background:

  • Over 150 chemical modifications on RNA molecules (mRNAs, rRNAs, tRNAs, ncRNAs) identified in 50 years.
  • RNA modifications regulate RNA biogenesis, biological functions, and are implicated in physiological processes and diseases, including cancer.
  • Growing interest in noncoding RNA (ncRNA) epigenetic modifications due to their critical roles in cancer.

Conclusions:

  • ncRNA modifications play significant roles in cancer.
  • RNA modifications offer potential as novel biomarkers for cancer detection.
  • Targeting RNA modifications presents a promising therapeutic strategy for cancer treatment.
Keywords:
Cancer progressionNoncoding RNAsRNA modificationsTherapeutic targets

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