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Updated: Jul 29, 2025

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Mechanical Ventilation: Negative to Positive and Back Again
1Keenan Research Centre, St Michael's Hospital, Unity Health Toronto, 209 Victoria Street, Room 4-08, Toronto, Ontario M5B 1T8, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Abstract:
Critical care and mechanical ventilation have a relatively brief history in medicine. Premises existed through the seventeenth to nineteenth centuries but modern mechanical ventilation started in the twentieth century. Noninvasive ventilation techniques had started both in the intensive care unit and for home ventilation at the end of the 1980s and the 1990s. The need for mechanical ventilation is increasingly influenced worldwide by the spread of respiratory viruses, and the last coronavirus disease 2019 pandemic has seen a massive successful use of noninvasive ventilation.
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