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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Polysaccharide‑platinum complexes for cancer theranostics.

Yunxia Yang1, Pengge Wang2, Zengrui Ji2

  • 1School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng 224007, China; Jiangsu Province Engineering Research Center of Agricultural Breeding Pollution Control and Resource, Yancheng Teachers University, Yancheng 224007, China; Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Yancheng 224007, China.

Carbohydrate Polymers
|May 25, 2023
PubMed
Summary

Platinum-polysaccharide complexes offer a promising approach to cancer therapy by enhancing drug delivery and antitumor effects. These novel complexes also show potential in improving immunotherapy efficiency for personalized cancer treatment.

Keywords:
AntitumorImmunoregulatoryImmunotherapyPlatinumPolysaccharides

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Area of Science:

  • Biochemistry
  • Materials Science
  • Pharmacology

Background:

  • Platinum anticancer drugs face challenges of systemic toxicity and drug resistance.
  • Natural polysaccharides possess diverse structures and pharmacological activities.
  • Combining platinum drugs with polysaccharides offers a strategy to overcome limitations.

Purpose of the Study:

  • To review the design, synthesis, characterization, and therapeutic applications of platinum-polysaccharide complexes.
  • To explore the multifunctional properties and cancer therapeutic potential of these complexes.
  • To summarize recent advancements in polysaccharide-based carriers and immunoregulatory activities.

Main Methods:

  • Classification of platinum-polysaccharide complexes by electronic charge.
  • Discussion of techniques for developing polysaccharide-based drug delivery systems.
  • Summary of immunoregulatory activities of polysaccharides.

Main Results:

  • Platinum-polysaccharide complexes exhibit enhanced drug accumulation and tumor selectivity.
  • These complexes achieve synergistic antitumor effects in cancer therapy.
  • Polysaccharides can trigger innate immune reactions, potentially enhancing immunotherapy.

Conclusions:

  • Platinum-polysaccharide complexes represent a promising multifunctional platform for cancer therapy.
  • Further strategies are needed to improve platinum-based personalized cancer treatment.
  • Integrating platinum-polysaccharide complexes with immunotherapy holds significant future potential.