Related Experiment Video

Updated: Jul 29, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

8.5K

New frontiers in quality control: the case of GPI-anchored proteins

Leticia Lemus1, Ramanujan S Hegde2, Veit Goder3

  • 1Department of Genetics, University of Seville, Seville, Spain. llemus@us.es.

Nature Reviews. Molecular Cell Biology
|May 25, 2023
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
07:57

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

8.5K
PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
10:58

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

Published on: July 27, 2017

9.5K

Related Experiment Videos

Last Updated: Jul 29, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
14:02

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

Published on: April 9, 2018

8.5K
Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
07:57

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

8.5K
PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
10:58

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

Published on: July 27, 2017

9.5K

Related Concept Videos

GPI Anchoring of Proteins in the ER Membrane01:29

GPI Anchoring of Proteins in the ER Membrane

4.2K
GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
4.2K

Articles linked to this work by shared authors, journal, and citation graph.

Mechanisms of Quality Control in GPI-Anchored Proteins: The Central Role of the Lipid Anchor.

International journal of molecular sciences·2026

Design principles of human membrane protein topology.

The Journal of cell biology·2026

O-mannosylation of misfolded ER proteins promotes ERAD.

The EMBO journal·2025

Global analysis of translocon remodeling during protein synthesis at the ER.

Nature structural & molecular biology·2025

Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control.

Science (New York, N.Y.)·2025

Identification of a factor that accelerates substrate release from the signal recognition particle.

Science (New York, N.Y.)·2024

The molecular basis of transcription initiation by RNA polymerase II.

Nature reviews. Molecular cell biology·2026

Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease.

Nature reviews. Molecular cell biology·2026

Mechanisms and balanced regulation of plant immunity.

Nature reviews. Molecular cell biology·2026

Regulation and roles of mammalian mitophagy.

Nature reviews. Molecular cell biology·2026

Mechanisms of transcription termination across the coding and noncoding loci of the genome.

Nature reviews. Molecular cell biology·2026

Structure and function of the outer kinetochore.

Nature reviews. Molecular cell biology·2026

Viral control of translation: rise of the ribosome.

Journal of virology·2026

FRET-based nanoprobes for nucleic acid sensing and disease diagnosis: materials, probe architectures, and analytical trends.

Journal of materials chemistry. B·2026

Integrating proteomics and metabolomics to reveal MAT2A for metabolic reprogramming in non-small cell lung cancer cells.

iScience·2026

N-propargylputrescine as a minimal-tag probe for imaging putrescine dynamics in cellular homeostasis and stress.

iScience·2026

Nanoparticle-Based Therapeutic Strategies for Pathological Cardiac Hypertrophy: Preclinical Advances, Translational Challenges, and Future Perspectives.

International journal of nanomedicine·2026

Long-term subclinical cardiac damage in people living with human immunodeficiency virus.

International journal of cardiology. Heart & vasculature·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us