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Related Experiment Videos

Hostility and recovery from melancholia.

G A Fava, R Kellner, J Lisansky

    The Journal of Nervous and Mental Disease
    |July 1, 1986
    PubMed
    Summary

    Major depressive illness treatment with amitriptyline reduced hostility and increased friendliness. Life events influenced hostility levels and treatment response in patients with depression.

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    Area of Science:

    • Psychiatry
    • Clinical Psychology
    • Pharmacology

    Background:

    • Major depressive illness with melancholia is associated with heightened hostility.
    • Understanding the impact of treatment on depressive symptoms and interpersonal functioning is crucial.

    Purpose of the Study:

    • To investigate the effect of amitriptyline on hostility and friendliness in major depressive illness patients.
    • To compare hostility levels in recovered patients with a normal control group.

    Main Methods:

    • Administered Kellner Symptom Questionnaire and Paykel's Clinical Interview for Depression to 20 inpatients before and after amitriptyline treatment.
    • Utilized a matched control group of normal subjects for comparative assessment.

    Main Results:

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    • Amitriptyline treatment led to decreased hostility and increased friendliness in depressed patients.
    • Hostility differences between recovered patients and controls diminished, unlike during illness.
    • Patients reporting prior losses showed higher friendliness and less hostility reduction post-treatment.

    Conclusions:

    • Hostility is a treatable symptom of depression, improving with interventions like amitriptyline.
    • Pre-illness life events, such as losses, may modulate hostility and treatment response in depression.