Preoptimisation in patients with acute obstructive colon cancer (PREOCC) - a prospective registration study protocol

Area of Science:

• Colorectal surgery
• Surgical oncology
• Gastroenterology

Background:

• High postoperative mortality and morbidity rates are observed in patients with obstructing colon cancer (OCC).
• Preoperative optimization shows promise in elective colorectal cancer (CRC) treatment.
• Focus on right-sided OCC is needed.

Purpose of the Study:

• To determine the feasibility of preoptimisation in OCC patients.
• To evaluate if preoptimisation reduces mortality and morbidity (stoma rates, complications) in OCC.
• To specifically investigate right-sided OCC.

Main Methods:

• Prospective registration study of OCC patients treated with curative intent.
• Preoptimisation protocol includes bowel decompression (NG-tube, SEMS, ostomy), nutritional support (parenteral/enteral), and physiotherapy.
• Primary endpoint: complication-free survival (CFS) at 90 days; secondary outcomes: complications, stoma rates, hospital stay, oncological outcomes.

Main Results:

• Study is prospective and open for inclusion.
• Preoptimisation protocol details are outlined.
• Primary and secondary endpoints are defined for evaluation.

Conclusions:

• Preoptimisation is expected to enhance preoperative patient condition.
• Improved preoperative health is anticipated to reduce postoperative complications in OCC.