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Updated: Jul 29, 2025

The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice
Published on: February 27, 2018
Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy
Yash Shashank Vakilna1, Ganne Chaitanya1, Muhammad Ubaid Hafeez1
1Texas Comprehensive Epilepsy Program, Department of Neurology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Abstract:
Deep brain stimulation (DBS) is a promising treatment for drug-refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15-17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real-time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.
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