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Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
Published on: September 22, 2017
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The Introduction of an MR-Conditional Prototype for Cardiopulmonary Bypass Support: Technical Aspects and System
Michael Hofmann1, Martin Schmiady1, Dominik Schulte2
1Clinic for Cardiac Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Summary
Researchers developed an MR-conditional cardiopulmonary bypass (CPB) system for brain perfusion studies in animal models. This novel heart-lung machine prototype is safe for use in magnetic fields, enabling advanced imaging during critical procedures.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Medical Imaging
Background:
- Complex congenital heart defects in newborns often necessitate cardiopulmonary bypass (CPB), but associated brain damage is a concern.
- Standard CPB devices contain metal components incompatible with Magnetic Resonance Imaging (MRI) due to safety risks.
- This limitation prevents in-situ cerebral perfusion assessment using MRI during CPB.
Purpose of the Study:
- To develop a prototype Magnetic Resonance Imaging (MRI)-conditional circulatory support system.
- To enable safe cerebral perfusion studies in animal models during CPB.
- To overcome the limitations of metal components in standard CPB devices within MRI environments.
Main Methods:
- Modification or replacement of ferromagnetic and metal components in a roller pump.
- Integration of an air-pressure motor to replace the standard drive system.
- Rigorous testing of all materials for MRI compatibility (ASTM F2503-13) and evaluation of technical performance parameters.
Main Results:
- The prototype MRI-conditional pump system operated safely within the magnetic field without causing image artifacts.
- Performance evaluations showed minor differences compared to standard CPB pumps.
- The system met essential requirements for operability, controllability, and flow range for planned animal studies.
Conclusions:
- The developed MR-conditional prototype is suitable for open-heart surgery in animal models.
- It enables brain perfusion assessment within an MRI environment.
- This technology advances the study of neurological complications associated with CPB.
