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Published on: June 2, 2014
Decision-making impairment under ambiguity but not under risk may underlie medication overuse in patients with
Chi Ieong Lau1,2,3,4,5, Wei-Hung Chen1,6, Han-Cheng Wang1,7
1Dementia Center, Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Objective:
To explore whether patients with chronic migraine and medication overuse headache (CM + MOH) present with decision-making deficit.
Background:
Factors underlying MOH in patients with CM remain unclear. Whether the process of decision-making plays a role in MOH is still controversial. Decision-making varies in the degree of uncertainty: under ambiguity where the probability of outcome is unknown, and under risk where probabilities are known.
Methods:
Decisions under ambiguity and risk were assessed with the Iowa Gambling Task and the Cambridge Gambling Task, respectively, whereas executive function was assessed by the Wisconsin Card Sorting Test.
Results:
A total of 75 participants: 25 patients with CM + MOH, 25 with CM, and 25 age- and sex-similar healthy controls (HCs), completed this cross-sectional study. There was no significant difference in headache profiles except for more frequent analgesic use (mean ± SD: 23.5 ± 7.6 vs. 6.8 ± 3.4 days; p < 0.001) and higher Severity of Dependence Scores (median [25th-75th percentile]: 8 [5-11] vs. 1 [0-4]; p < 0.001) in patients with CM + MOH compared to CM. Total net score (mean ± SD) on the Iowa Gambling Task in patients with CM + MOH, CM, and HCs were - 8.1 ± 28.7, 10.9 ± 29.6, and 14.2 ± 28.8, respectively. There was a significant difference between the three groups (F(2, 72) = 4.28, p = 0.017), with patients with CM + MOH making significantly more disadvantageous decisions than patients with CM (p = 0.024) and HCs (p = 0.008), while the CM and HC groups did not differ (p = 0.690). By contrast, there was no significant difference between the groups in the Cambridge Gambling Task and the Wisconsin Card Sorting Test. Furthermore, performance on the Iowa Gambling Task was inversely correlated with analgesic consumption (r = -0.41, p = 0.003), suggesting that decision-making under ambiguity may be related to MOH.
Conclusions:
Our data suggest that patients with CM + MOH had impaired decisions under ambiguous, but not risky situations. This dissociation indicates disrupted emotional feedback processing rather than executive dysfunction, which may underlie the pathogenesis of MOH.
Insights
Patients with chronic migraine plus medication overuse headache (CM+MOH) exhibit impaired decision-making under ambiguity, suggesting emotional feedback processing deficits contribute to MOH development.
Area of Science:
- Neuroscience
- Psychology
- Neurology
Background:
- The underlying factors of medication overuse headache (MOH) in chronic migraine (CM) patients are not fully understood.
- The role of decision-making processes, particularly under conditions of uncertainty (ambiguity and risk), in the development of MOH remains controversial.
Purpose of the Study:
- To investigate whether patients with chronic migraine and medication overuse headache (CM+MOH) exhibit deficits in decision-making.
- To differentiate decision-making abilities under ambiguity versus risk in CM+MOH patients.
Main Methods:
- A cross-sectional study involving 75 participants: 25 with CM+MOH, 25 with CM, and 25 healthy controls (HCs).
- Decision-making under ambiguity was assessed using the Iowa Gambling Task (IGT).
- Decision-making under risk was assessed using the Cambridge Gambling Task (CGT), and executive function was assessed using the Wisconsin Card Sorting Test (WCST).
Main Results:
- Patients with CM+MOH demonstrated significantly more disadvantageous decisions on the IGT compared to both CM patients and HCs.
- No significant differences were found between CM+MOH patients, CM patients, and HCs on the CGT or WCST.
- Performance on the IGT was inversely correlated with the frequency of analgesic use, suggesting a link between decision-making under ambiguity and MOH.
Conclusions:
- Patients with CM+MOH show impaired decision-making specifically in ambiguous situations, not in risky ones.
- This dissociation suggests that the pathogenesis of MOH may involve disrupted emotional feedback processing rather than general executive dysfunction.
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