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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis and Coordination of a Bisphosphine-[NHC-borane] Compound: A Ligand Framework for Bimetallic Structure
Aurèle Camy1, Laure Vendier1, Christian Bijani1
1LCC-CNRS, Université de Toulouse, CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 04, France.
Abstract:
We report herein the synthesis of a bisphosphine-[NHC-BH3] compound and its coordination toward gold. The ligand is shown to support a bimetallic structure bisphosphine-[NHC-BH3](AuCl)2. The abstraction of one chloride from the gold metal center triggers the activation of a BH3 fragment, leading to the reductive elimination of H2 and the formation of a dicationic Au42+ complex featuring Au centers at the +0.5 oxidation state, via a (μ-H)Au2 intermediate, characterized in situ at 183 K. The reactivity of Au4 with thiophenol led to the reoxidation of the gold metal centers to a (μ-S(Ph))Au2 complex. In the different complexes, borane fragment was shown to bridge the Au2 core via weak interaction with [BH], [BCl], and [BH2] moieties.
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