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Sexual Dysfunction in Multiple Sclerosis: The Role of Executive Function.

Silvia Marinetto1, Alice Riccardi2, Filippo Barbadoro1

  • 1Department of Philosophy, Sociology, Education and Applied Psychology, University of Padua, 35133 Padua, Italy.

Behavioral Sciences (Basel, Switzerland)
|May 26, 2023
PubMed
Summary

Sexual difficulties in Multiple Sclerosis (MS) are linked to cognitive deficits, especially executive dysfunction, not memory or attention issues. Depression also significantly impacts sexual health in MS patients.

Keywords:
Multiple Sclerosiscognitive abilitiesdepressionexecutive functionsself-perceptionsexual dysfunction

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Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Rehabilitation Medicine

Background:

  • Multiple Sclerosis (MS) frequently presents with cognitive impairment and sexual dysfunction.
  • Understanding the interplay between these symptoms is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate the relationship between specific cognitive domains and sexual difficulties in individuals with MS.
  • To determine the influence of executive functions, memory, and attention on sexual dysfunction in MS.
  • To explore the combined impact of cognitive deficits and depression on sexual health in MS.

Main Methods:

  • Fifty-five individuals diagnosed with MS participated in the study.
  • Cognitive function was assessed using the Selective Reminding Test (memory), Symbol Digit Modalities Test (attention), D-KEFS Sorting Test, and Stroop Test (executive functions).
  • Sexual function, depression, and self-perceived cognition were evaluated using the Multiple Sclerosis Intimacy and Sexuality Questionnaire-19, Beck Depression Inventory-II, and Self-perception of Cognition in Multiple Sclerosis, respectively.

Main Results:

  • Sexual difficulties in MS were significantly associated with deficits in executive functions.
  • No significant association was found between sexual difficulties and impairments in memory or attention.
  • Depression symptoms were identified as a significant factor contributing to sexual difficulties in this population.

Conclusions:

  • Executive dysfunction plays a key role in the sexual difficulties experienced by individuals with MS.
  • Cognitive impairment and depression interact to influence sexual health outcomes in MS.
  • Targeting executive function deficits and managing depression may be important for improving sexual well-being in MS patients.