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Medication-Related Osteonecrosis: Why the Jawbone?
Sydney Kuehn1, Rafaela Scariot2, Mohammed Elsalanty1
1Department of Medical Anatomical Sciences, College of Osteopathic Medicine of the Pacific, Pomona, CA 91766, USA.
Dentistry Journal
|May 26, 2023
Summary
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but severe complication of anti-resorptive drugs. This review explores why the jawbone is uniquely susceptible to MRONJ, unlike other skeletal sites.
Area of Science:
- Oral and Maxillofacial Surgery
- Pharmacology
- Bone Biology
Background:
- Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse effect of anti-resorptive medications.
- Despite systemic drug effects, MRONJ predominantly affects the jawbones.
- Current understanding of MRONJ pathogenesis and prevention strategies remains limited.
Purpose of the Study:
- To investigate the unique susceptibility of the jawbone to MRONJ.
- To explore the multifactorial pathogenesis of MRONJ.
- To identify potential new directions for MRONJ prevention and treatment.
Main Methods:
- Literature review and synthesis of existing research on MRONJ.
- Analysis of the unique characteristics of the oral microenvironment.
- Comparative study of bone metabolism in the jaw versus other skeletal sites.
Main Results:
- The jawbone's unique anatomical and physiological features may predispose it to MRONJ.
- Specific factors within the oral microenvironment contribute to MRONJ development.
- Understanding these unique factors is crucial for targeted prevention and management.
Conclusions:
- The jawbone's distinct susceptibility to MRONJ warrants further investigation.
- Targeting the oral microenvironment may offer novel strategies for MRONJ prevention.
- Further research into the multifactorial pathogenesis of MRONJ is essential.
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