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Related Experiment Video

Updated: Jul 29, 2025

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A Novel Bio-Adhesive Mesh System for Medical Implant Applications: In Vivo Assessment in a Rabbit Model.

Melinda Harman1,2, Kevin Champaigne1,3, William Cobb2

  • 1301 Rhodes Engineering Research Center, Bioengineering Department, Clemson University, Clemson, SC 29634, USA.

Gels (Basel, Switzerland)
|May 26, 2023
PubMed
Summary

A new bio-adhesive mesh system improves surgical mesh fixation for hernia repair. This novel system enhances adhesion to polymer biomaterials, outperforming traditional fibrin sealants in preclinical trials.

Keywords:
herniain vivo animal modelpoloxamine hydrogel adhesivepolymer brushespolypropylenesurgical mesh“grafting to” surface modification

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Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Tissue Engineering

Background:

  • Injectable surgical sealants and adhesives often exhibit poor adhesion to polymer biomaterials common in medical implants.
  • Existing sealants like fibrin gels and hydrogels adequately adhere to biological tissues but not synthetic implant surfaces.
  • This limitation hinders the development of effective and secure medical devices, particularly for procedures like hernia repair.

Purpose of the Study:

  • To develop and evaluate a novel bio-adhesive mesh system for enhanced fixation of polymer biomaterials in medical applications.
  • To improve the adhesion of surgical meshes to polymer substrates, addressing the limitations of current sealants.
  • To assess the in vivo performance and surgical utility of the developed bio-adhesive mesh system for abdominal hernia repair.

Main Methods:

  • Development of a bio-adhesive mesh system combining a bifunctional poloxamine hydrogel adhesive with a poly-glycidyl methacrylate (PGMA) surface modification grafted with human serum albumin (HSA).
  • In vitro testing to evaluate adhesive strength of the modified mesh compared to unmodified mesh.
  • In vivo evaluation in a rabbit model for abdominal hernia repair, assessing mesh slippage, contraction, fixation via tensile testing, and biocompatibility through histology.

Main Results:

  • The novel PGMA/HSA grafted mesh with hydrogel adhesive demonstrated significantly improved in vitro adhesive strength compared to unmodified mesh.
  • In vivo studies showed superior mesh fixation and reduced slippage/contraction compared to polypropylene mesh fixed with fibrin sealant.
  • Histological analysis revealed good tissue integration within the bio-adhesive mesh pores after 42 days, indicating biocompatibility.

Conclusions:

  • The developed bio-adhesive mesh system, utilizing PGMA/HSA grafted polypropylene and a bifunctional poloxamine hydrogel adhesive, offers superior fixation for medical implants.
  • This innovative system shows significant promise for improving surgical outcomes in applications like abdominal hernia repair.
  • The findings support the clinical translation of this bio-adhesive technology for enhanced medical device performance.