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Onychomycosis: Old and New
Narges Maskan Bermudez1, Giselle Rodríguez-Tamez2, Sofia Perez1
1Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33125, USA.
Journal of Fungi (Basel, Switzerland)
|May 26, 2023
Summary
Onychomycosis, a chronic fungal nail infection, has limited oral treatment success. This review examines current and novel oral therapies for fungal nail infections, addressing emerging drug resistance.
Area of Science:
- Dermatology
- Mycology
- Pharmacology
Background:
- Onychomycosis is a prevalent chronic fungal infection affecting the nail plate.
- It leads to nail discoloration and thickening, impacting quality of life.
- Current treatments face challenges with limited efficacy and developing resistance.
Purpose of the Study:
- To review existing oral treatment options for onychomycosis.
- To explore emerging novel oral drugs for fungal nail infections.
- To address the issue of terbinafine resistance in onychomycosis treatment.
Main Methods:
- Systematic literature review of current and investigational oral therapies.
- Analysis of clinical trial data and resistance patterns.
- Evaluation of drug efficacy, safety, and resistance profiles.
Main Results:
- Terbinafine and itraconazole are approved oral treatments; fluconazole is used off-label.
- Cure rates for existing therapies are suboptimal.
- Worldwide resistance to terbinafine is an increasing concern.
Conclusions:
- Current oral therapies for onychomycosis have limitations in efficacy and are facing resistance.
- Novel oral antifungal agents show promise for improved treatment outcomes.
- Further research into new drugs is crucial for managing onychomycosis effectively.
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