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An Eco-Friendly Process to Extract Hydroxyapatite from Sheep Bones for Regenerative Medicine: Structural, Morphologic
Sílvia Rodrigues Gavinho1, Mehmet Bozdag2, Cevriye Kalkandelen3
1I3N and Physics Department, University of Aveiro, 3810-193 Aveiro, Portugal.
Journal of Functional Biomaterials
|May 26, 2023
Summary
Hydroxyapatite derived from sheep bones, enhanced with magnesium, shows improved electrical properties for bone regeneration. This sustainable source offers promising applications in regenerative medicine.
Area of Science:
- Biomaterials Science
- Materials Science
- Regenerative Medicine
Background:
- Hydroxyapatite (HA) is crucial for bone tissue engineering due to its biocompatibility and osteointegration capabilities.
- Electrical properties and ion doping, like magnesium, can further enhance HA's biological performance.
- Sustainable and cost-effective sources of HA are needed for broader applications.
Purpose of the Study:
- To extract hydroxyapatite from sheep femur bones.
- To investigate the structural and electrical properties of HA with varying magnesium oxide (MgO) content.
- To assess the potential of sheep-derived HA for regenerative medicine.
Main Methods:
- Extraction of hydroxyapatite from sheep femur bones.
- Characterization using Differential Thermal Analysis (DTA), X-ray Diffraction (XRD), density, Raman spectroscopy, and Fourier-Transform Infrared (FTIR) spectroscopy.
- Morphological analysis via Scanning Electron Microscopy (SEM) and electrical property measurements (frequency and temperature dependence).
Main Results:
- Magnesium oxide solubility was below 5% wt for heat treatments at 600 °C.
- Increased magnesium oxide content enhanced the electrical charge storage capacity of the hydroxyapatite.
- Sheep-derived hydroxyapatite demonstrated favorable structural and electrical characteristics.
Conclusions:
- Sheep femur bones provide a sustainable and low-cost source of hydroxyapatite.
- The addition of magnesium oxide improves the electrical properties of hydroxyapatite.
- This modified hydroxyapatite shows significant promise for applications in regenerative medicine and bone tissue engineering.
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