Mapping current status and emerging trends in NETosis: A bibliometric study.

Area of Science:

• Immunology
• Cell Biology
• Biomedicine

Background:

• NETosis is a key neutrophil innate immune mechanism.
• It significantly contributes to autoimmune diseases, thrombosis, cancer, and COVID-19 progression.
• Bibliometric analysis provides an objective overview of knowledge dynamics in NETosis research.

Purpose of the Study:

• To qualitatively and quantitatively analyze the literature on NETosis.
• To understand the knowledge dynamics and research trends in the field.
• To identify influential countries, institutions, authors, and publications.

Main Methods:

• Bibliometric analysis of literature from Web of Science Core Collection.
• Utilized VOSviewer, CiteSpace, and Microsoft for co-authorship, co-occurrence, and co-citation analysis.
• Identified top keywords and burst detection trends.

Main Results:

• The United States leads in NETosis research; Harvard University is the most active institution.
• Mariana J. Kaplan and Brinkmann V are highly influential authors.
• Key journals include Frontiers in Immunology, Blood, and Nature Medicine.
• Emerging research focuses on COVID-19 and cancer, with keywords like 'cytokine storm' and 'circulating tumor cell' showing strong bursts.

Conclusions:

• NETosis research is experiencing significant growth.
• Current focus is on NETosis mechanisms, innate immunity, autoimmune diseases (lupus, rheumatoid arthritis), and thrombosis.
• Future research will investigate NETosis in COVID-19 and cancer metastasis.