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A case of collagenous gastritis and literature review: A case report
Channi Wu1, Lin Wang1, Lan Zhang2
1Department of Gastroenterology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, China.
Insights
Collagenous gastritis, a rare condition, can present with iron-deficiency anemia. Prompt diagnosis through clinical, endoscopic, and pathological evaluation is crucial for effective management.
Area of Science:
- Gastroenterology
- Pathology
Background:
- Collagenous gastritis (CG) is an uncommon gastrointestinal disorder.
- CG often presents with nonspecific symptoms, making diagnosis challenging.
Observation:
- A 26-year-old woman presented with chronic upper abdominal distention and iron-deficiency anemia.
- Gastroscopy revealed diffuse nodular mucosa, and biopsy confirmed a thickened subepithelial collagen band characteristic of CG.
Findings:
- Treatment with a polysaccharide iron complex and omeprazole improved the patient's symptoms.
- Hemoglobin levels increased to 91 g/L after 8 weeks of therapy, indicating successful management of anemia.
Implications:
- This case highlights the importance of a multidisciplinary diagnostic approach for CG.
- Early recognition and treatment can alleviate symptoms and correct associated anemia.
Rational:
Collagenous gastritis (CG) is rarely encountered in clinical practice. Here, we reported a case of CG with iron-deficiency anemia as the main symptom.
Patient Concerns:
The patient was a 26-year-old woman who sought medical advice with a chief complaint of recurrent upper abdominal distention and anemia since the last 3 years.
Diagnoses:
Gastroscopy at admission showed diffuse nodular mucosa. The pathology showed the formation of a belt hyperplasia of collagen in the superficial mucosa along with the infiltration of inflammatory cells. The subepithelial collagen band was 17.68 to 35.73-μm thick and tested positive for Masson staining, thereby confirming the diagnosis of CG.
Interventions:
A polysaccharide iron complex capsule was given in a dosage of 0.3 t.i.d., p.o. in combination with an omeprazole capsule (20 mg q.d. p.o).
Outcomes:
The symptoms (upper abdominal distention and anemia) were ameliorated after 8-week treatment. Blood routine showed that the hemoglobin level rose to 91 g/L.
Lessons:
It is difficult to diagnose CG. Hence, a comprehensive examination based on clinical manifestations, endoscopic findings, and pathological features is required.
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