Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Applications Of NMR In Biology01:25

Applications Of NMR In Biology

3.8K
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel and traditional anthropometric measures of obesity association with dynapenia in postmenopausal women.

Menopause (New York, N.Y.)·2026
Same author

Benchtop NMR as a clinical tool for acute respiratory illness: metabolic signatures associated with disease severity.

Respiratory research·2026
Same author

Higher endometrial thickness prior frozen embryo transfer is associated with lower first-trimester placental growth factor.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same author

Pharmacokinetic analysis of nacubactam, a novel β-lactamase inhibitor, co-administered with meropenem in patients with a complicated urinary tract infection.

JAC-antimicrobial resistance·2026
Same author

Metabolic and endocrine factors involved in handgrip strength and dynapenia in postmenopausal women.

Maturitas·2026
Same author

A multi-center, open-label, two-part study to investigate the effect of renal function and hemodialysis on the pharmacokinetics of the novel β-lactamase inhibitor nacubactam.

Antimicrobial agents and chemotherapy·2026

Related Experiment Video

Updated: Jul 29, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

590

Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application.

Pilar Alonso-Moreno1, Ignacio Rodriguez1,2,3, Jose Luis Izquierdo-Garcia1,2,3

  • 1NMR and Imaging in Biomedicine Group, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Metabolites
|May 26, 2023
PubMed
Summary
This summary is machine-generated.

Benchtop Nuclear Magnetic Resonance (NMR) offers a cost-effective solution for metabolomics, enabling disease biomarker discovery in clinical settings. This technology shows promise for diagnosing and managing conditions like type 2 diabetes and tuberculosis.

Keywords:
benchtopbiomarkersdiabetesdiagnosislow fieldmetabolitesmetabolomicsnuclear magnetic resonancetuberculosis

More Related Videos

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy
07:54

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy

Published on: December 15, 2011

13.2K
Pure Shift Nuclear Magnetic Resonance: a New Tool for Plant Metabolomics
13:16

Pure Shift Nuclear Magnetic Resonance: a New Tool for Plant Metabolomics

Published on: July 31, 2021

1.9K

Related Experiment Videos

Last Updated: Jul 29, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

590
Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy
07:54

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy

Published on: December 15, 2011

13.2K
Pure Shift Nuclear Magnetic Resonance: a New Tool for Plant Metabolomics
13:16

Pure Shift Nuclear Magnetic Resonance: a New Tool for Plant Metabolomics

Published on: July 31, 2021

1.9K

Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Clinical Diagnostics

Background:

  • Nuclear Magnetic Resonance (NMR)-based metabolomics is crucial for disease biomarker identification.
  • High costs and large size of traditional NMR spectrometers limit clinical translation.
  • Benchtop NMR presents a compact, affordable alternative for wider clinical adoption.

Purpose of the Study:

  • To review the current applications of benchtop NMR in clinical settings.
  • To highlight benchtop NMR's potential in disease biomarker discovery and metabolic profiling.
  • To assess the feasibility of benchtop NMR for routine clinical use.

Main Methods:

  • Review of existing literature on benchtop NMR applications in metabolomics.
  • Analysis of studies demonstrating benchtop NMR's ability to detect metabolite changes in biofluids.
  • Evaluation of reproducibility and accuracy of benchtop NMR for biomarker detection.

Main Results:

  • Benchtop NMR successfully detects metabolite level changes linked to type 2 diabetes and tuberculosis.
  • Metabolic biomarkers identified in urine, blood plasma, and saliva using benchtop NMR.
  • Demonstrated reproducibility in detecting disease-associated metabolic alterations.

Conclusions:

  • Benchtop NMR is a viable, cost-effective tool for clinical metabolomics.
  • Further research is needed to optimize protocols and expand biomarker identification.
  • Benchtop NMR has the potential to revolutionize disease diagnosis, prognosis, and treatment monitoring.