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Updated: Jul 29, 2025

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
Published on: November 29, 2018
Visible-Light-Induced Four-Component Ritter-Type Reaction: Access to β-Trifluoromethyl Imides
Ransong Ma1, Yuanyuan Ren1, Zhoubin Deng1
1College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, P. R. China.
Abstract:
A visible-light-induced four-component Ritter-type reaction was developed for the synthesis of β-trifluoromethyl imides from CF3Br, alkenes, carboxylic acids, and nitriles. This protocol features mild reaction conditions, a broad substrate scope, and excellent functional group compatibility. Furthermore, this method has been proven to be suitable for the late-stage diversification of drug molecules. A mechanism involving a Ritter-type reaction and Mumm rearrangement was proposed on the basis of the control experiments.
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