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The KL genetic polymorphisms Associated with type 2 diabetes Mellitus.

Hyun-Seok Jin1, Dongju Jung1,2

  • 1Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, 31499 Asan, Chungnam Republic of Korea.

Indian Journal of Clinical Biochemistry : IJCB
|May 26, 2023
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Summary

The anti-aging gene Klotho (KL) is linked to Type 2 Diabetes Mellitus (T2DM). Specific KL gene variations (SNPs) were found to increase the risk of developing T2DM in an Asian population.

Keywords:
Cohort studiesDiabetes Mellitus Type 2Polymorphism, single nucleotide

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Area of Science:

  • Genetics
  • Endocrinology
  • Metabolic Diseases

Background:

  • The Klotho (KL) gene, known for its anti-aging properties, has been increasingly associated with Type 2 Diabetes Mellitus (T2DM).
  • Understanding the genetic basis of this association is crucial for identifying T2DM risk factors.

Purpose of the Study:

  • To genetically analyze the association between Klotho (KL) gene single nucleotide polymorphisms (SNPs) and Type 2 Diabetes Mellitus (T2DM) in an Asian cohort.
  • To identify specific KL SNPs that may serve as risk markers for T2DM.

Main Methods:

  • Utilized data from the Korean Association Resource (KARE) database, examining 20 KL SNPs.
  • Performed statistical analyses using additive, dominant, and recessive genetic models.
  • Employed imputed KL SNPs from HapMap reference data for further analysis.

Main Results:

  • Twelve out of 20 KL SNPs showed a significant association with T2DM under additive and dominant models.
  • Odds ratios indicated that these KL SNPs increase susceptibility to T2DM.
  • Significant KL SNPs, including imputed ones, were distributed across the KL gene region.

Conclusions:

  • Klotho plays a significant role in the development of Type 2 Diabetes Mellitus.
  • Identified KL SNPs represent potential risk markers for T2DM in the Asian cohort studied.