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The KL genetic polymorphisms Associated with type 2 diabetes Mellitus
Hyun-Seok Jin1, Dongju Jung1,2
1Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, 31499 Asan, Chungnam Republic of Korea.
Indian Journal of Clinical Biochemistry : IJCB
|May 26, 2023
Summary
The anti-aging gene Klotho (KL) is linked to Type 2 Diabetes Mellitus (T2DM). Specific KL gene variations (SNPs) were found to increase the risk of developing T2DM in an Asian population.
Area of Science:
- Genetics
- Endocrinology
- Metabolic Diseases
Background:
- The Klotho (KL) gene, known for its anti-aging properties, has been increasingly associated with Type 2 Diabetes Mellitus (T2DM).
- Understanding the genetic basis of this association is crucial for identifying T2DM risk factors.
Purpose of the Study:
- To genetically analyze the association between Klotho (KL) gene single nucleotide polymorphisms (SNPs) and Type 2 Diabetes Mellitus (T2DM) in an Asian cohort.
- To identify specific KL SNPs that may serve as risk markers for T2DM.
Main Methods:
- Utilized data from the Korean Association Resource (KARE) database, examining 20 KL SNPs.
- Performed statistical analyses using additive, dominant, and recessive genetic models.
- Employed imputed KL SNPs from HapMap reference data for further analysis.
Main Results:
- Twelve out of 20 KL SNPs showed a significant association with T2DM under additive and dominant models.
- Odds ratios indicated that these KL SNPs increase susceptibility to T2DM.
- Significant KL SNPs, including imputed ones, were distributed across the KL gene region.
Conclusions:
- Klotho plays a significant role in the development of Type 2 Diabetes Mellitus.
- Identified KL SNPs represent potential risk markers for T2DM in the Asian cohort studied.
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