Related Experiment Video

Updated: Jul 29, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Microscopic Polyangiitis with Pulmonary-renal Involvement in a Patient with Polyarticular Juvenile Idiopathic

Mavidi S Kumar1, Sumantro Mondal1, Geetabali Sircar1

  • 1Department of Clinical Immunology and Rheumatology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Indian Journal of Nephrology
|May 26, 2023
PubMed

Insights

The rare co-occurrence of polyarticular juvenile idiopathic arthritis (p-JIA) and microscopic polyangiitis (MPA) is presented in a 26-year-old female. Successful treatment involved corticosteroids and rituximab for this unique case.

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Polyarticular juvenile idiopathic arthritis (p-JIA) is a chronic autoimmune condition.
  • Microscopic polyangiitis (MPA) is a rare systemic vasculitis.

Observation:

  • A 26-year-old female with a 15-year history of rheumatoid factor-positive p-JIA developed MPA.
  • The patient presented with MPA involving renal and pulmonary systems.

Findings:

  • This case highlights the extremely rare association between p-JIA and MPA.
  • Successful treatment was achieved using intravenous corticosteroids and rituximab.

Implications:

  • This report expands understanding of rare autoimmune disease comorbidities.
  • It underscores the importance of considering MPA in p-JIA patients with new organ-specific symptoms.
Keywords:
Microscopic polyangiitispolyarticular juvenile idiopathic arthritispulmonaryrenal

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