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CircRNA-miRNA-VEGFA: an important pathway to regulate cancer pathogenesis
Lei Zhang1, Yuan Zhang1, Xin Li1
1Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
Frontiers in Pharmacology
|May 26, 2023
Summary
Circular RNAs (circRNAs) are stable molecules that regulate cancer development by controlling vascular endothelial growth factor-A (VEGFA) levels through microRNA interactions, impacting cancer pathogenesis.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Malignant tumors cause high mortality and economic burden globally.
- Vascular endothelial growth factor-A (VEGFA) and circular RNAs (circRNAs) are implicated in cancer pathogenesis.
- VEGFA is crucial for angiogenesis, a key process in cancer development.
Purpose of the Study:
- To explore the origin and functional pathways of VEGFA.
- To review the properties and mechanisms of circRNAs.
- To summarize the role of circRNAs in regulating VEGFA during cancer pathogenesis.
Main Methods:
- Literature review on VEGFA and circRNA.
- Analysis of circRNA properties and action mechanisms.
- Summary of circRNA-VEGFA interactions in cancer.
Main Results:
- CircRNAs are stable molecules with diverse regulatory functions.
- CircRNAs can act as transcriptional regulators, miRNA/RNA binding protein sponges, and protein templates.
- CircRNAs regulate VEGFA levels, influencing cancer development through miRNA binding.
Conclusions:
- CircRNAs play a significant role in cancer pathogenesis by modulating VEGFA.
- Understanding circRNA-VEGFA interactions offers potential therapeutic targets for cancer.
- Further research into circRNA mechanisms is essential for cancer treatment strategies.
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