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Endocarditis with Streptococcus pseudoporcinus Associated with Mastocytosis and Spondylodiscitis-A Coincidental

Victoria Birlutiu1, Rares-Mircea Birlutiu2, Minodora Teodoru1

  • 1Faculty of Medicine, Lucian Blaga University of Sibiu, County Clinical Emergency Hospital Sibiu, Str. Lucian Blaga, Nr. 2A, 550169 Sibiu, Romania.

Tropical Medicine and Infectious Disease
|May 26, 2023
PubMed

Insights

This study reports a rare case of Streptococcus pseudoporcinus infective endocarditis with spondylodiscitis in a patient with undiagnosed systemic mastocytosis. The findings highlight the bacterium

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Hematology

Background:

  • Streptococcus pseudoporcinus, a bacterium typically found in the genitourinary tract, has been rarely associated with severe infections.
  • Infective endocarditis and spondylodiscitis are serious conditions that require prompt diagnosis and treatment.

Observation:

  • A 63-year-old patient with undiagnosed systemic mastocytosis presented with symptoms suggestive of endocarditis and spinal infection.
  • Blood cultures identified Streptococcus pseudoporcinus, and imaging revealed mitral valve vegetations and L5-S1 spondylodiscitis with abscess formation.
  • Bone marrow examination confirmed mastocytosis, indicating a potential underlying immunodeficiency or pro-inflammatory state.

Findings:

  • The patient was diagnosed with Streptococcus pseudoporcinus infective endocarditis and spondylodiscitis.
  • Despite initial antibiotic treatment, the patient developed a mitral valve abscess, necessitating surgical intervention.
  • Successful mitral valve replacement and continued antibiotic therapy led to a favorable outcome.

Implications:

  • This case underscores the potential of Streptococcus pseudoporcinus to cause severe invasive infections, even in non-immunocompromised individuals.
  • The association with systemic mastocytosis suggests that underlying conditions may predispose individuals to such infections.
  • Findings emphasize the importance of considering rare pathogens in complex cases and the need for comprehensive patient evaluation.
Keywords:
Streptococcus pseudoporcinuscase reportinfective endocarditisspondylodiscitissystemic mastocytosis

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