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How accurate is urine cytology?
Journal of the Royal Society of Medicine
|June 1, 1986
Summary
Exfoliative urinary cytology effectively detects urothelial cancers, especially larger, invasive tumors. This diagnostic method aids in identifying malignancies in less accessible urinary tract areas.
Area of Science:
- Urology
- Oncology
- Cytopathology
Background:
- Urothelial carcinoma is a significant malignancy.
- Accurate diagnostic methods are crucial for effective treatment.
- Urinary cytology is a non-invasive diagnostic technique.
Purpose of the Study:
- To evaluate the efficacy of exfoliative urinary cytology in detecting urothelial cancer.
- To correlate cytology findings with tumor characteristics and TNM staging.
Main Methods:
- Exfoliative urinary cytology was performed on 260 patients with histologically proven urothelial cancer.
- Tumor site, size, shape, histological grade, and TNM classification were documented.
Main Results:
- Overall, urine cytology was positive in 52% of cases, suspicious in 11%, and negative in 38%.
- Positive cytology was associated with large, papillary, solid, poorly differentiated, and invasive tumors (T2-4).
- Upper tract tumors and those in bladder diverticula showed higher positive cytology rates.
Conclusions:
- Exfoliative urinary cytology is a valuable tool for detecting urothelial tumors, particularly high-grade and invasive types.
- The technique is useful for diagnosing malignancies in less accessible urinary tract locations, including in-situ carcinoma.