Racial Differences in Aging-Related Deficits Among Older Adults With Colorectal Cancer

Area of Science:

• Geriatric Oncology
• Health Disparities
• Colorectal Cancer Research

Background:

• Race and aging significantly impact colorectal cancer (CRC) outcomes, yet their intersection with aging-related impairments is understudied.
• Existing literature lacks comprehensive analysis of racial differences in frailty and geriatric deficits among CRC patients.

Purpose of the Study:

• To investigate racial disparities in frailty and specific geriatric deficit domains within a cohort of older adults diagnosed with colorectal cancer.
• To identify if race is independently associated with increased frailty and functional decline in CRC patients, considering social determinants.

Main Methods:

• Retrospective analysis of data from the Cancer and Aging Resilience Evaluation (CARE) registry at a comprehensive cancer center.
• Inclusion of older adults (≥60 years) with colorectal cancer, comparing Black and White patient groups.
• Assessment of frailty, physical function, functional status, cognitive complaints, psychological function, and health-related quality of life.

Main Results:

• Black patients exhibited higher social vulnerability index and limited social support compared to White patients.
• After adjusting for covariates, Black patients had significantly higher odds of frailty (aOR 3.77), physical limitations (aOR 1.93), functional limitations (aOR 3.21), and poorer quality of life (aOR 2.45).
• These disparities persisted across different cancer stages (I-III vs. IV).

Conclusions:

• Black older adults with colorectal cancer are more likely to experience frailty and deficits in physical and functional status, and quality of life compared to White patients.
• Geriatric assessment tools are crucial for identifying and addressing racial inequities in the care and outcomes of older adults with colorectal cancer.