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Colorable role of interleukin (IL)-6 in obesity hypertension: A hint from a Chinese adult case-control study

Ou Wu1, Chengda Yuan2, Jianhang Leng3

  • 1Shulan International Medical College, Zhejiang Shuren University, Zhejiang, China.

Cytokine
|May 26, 2023
PubMed

Insights

Interleukin-6 (IL-6) shows varied effects in obesity-hypertension, influencing blood pressure and inflammation differently based on disease presence. Further research is needed to understand IL-6

Area of Science:

  • Cardiovascular Disease Research
  • Immunology and Inflammation
  • Metabolic Disorders

Background:

  • Obesity and hypertension are leading global risk factors for cardiovascular diseases.
  • Both conditions are linked to chronic low-grade inflammation mediated by cytokines like interleukin-6 (IL-6).
  • The precise role of IL-6 in hypertension associated with obesity remains unclear.

Purpose of the Study:

  • To investigate the impact of IL-6 on blood pressure, inflammation, and metabolic function in individuals with obesity and hypertension.
  • To conduct a case-control study in a Chinese adult population.

Main Methods:

  • 153 participants were categorized into four groups: normal healthy (NH), obesity only (JO), hypertension only (JH), and obesity-hypertension (OH).
  • Serum IL-6 concentrations were quantified using Enzyme-linked Immunosorbent Assay (ELISA).
  • Correlations between IL-6 levels and anthropometric/laboratory parameters were analyzed, alongside differences across subgroups. Multiple linear regression identified predictors of serum IL-6.

Main Results:

  • Serum IL-6 was higher in the NH group compared to the JO group.
  • Positive correlation between IL-6 and diastolic blood pressure was observed in NH and JO groups, but not in JH and OH groups.
  • IL-6 correlated with albumin (NH), alkaline phosphatase (JO), serum creatinine, and fasting blood glucose (JH). Predictors of IL-6 varied significantly across groups.

Conclusions:

  • IL-6 appears to exert diverse effects in the pathogenesis of obesity-hypertension, influenced by the presence of either or both conditions.
  • Further investigation is required to fully elucidate the mechanisms of IL-6 signaling and its functional role in these diseases.
Abstract

Keywords:
Blood pressureBody mass indexHypertensionObesityinterleukin (IL)-6

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