Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Motor Units01:13

Motor Units

4.1K
The motor unit is a fundamental component of the neuromuscular system and plays a crucial role in coordinating muscle contractions. It consists of a somatic motor neuron, which connects and controls multiple skeletal muscle fibers, forming a single functional segment. The axon of the motor neuron branches out and establishes synaptic connections known as neuromuscular junctions with individual muscle fibers within the motor unit.
Motor units come in different sizes, with smaller units...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal summation of subthreshold stimuli in human motor axons: Implications for intraoperative neuromonitoring.

Clinical neurophysiology practice·2026
Same author

Neuroplastic adaptation in somatosensory representation in congenital limb deficiency: A case-control study.

Neuropsychologia·2025
Same author

DICOM encoding of annotation and montage data for waveform recordings.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025
Same author

Electrodiagnostic criteria for neuromuscular transmission disorders suggested by a European consensus group.

Clinical neurophysiology practice·2025
Same author

Barriers and new opportunities in developing effective therapies for diabetic neuropathy: International expert consensus recommendations.

Diabetes research and clinical practice·2025
Same author

EEG for good outcome prediction after cardiac arrest: A multicentre cohort study.

Resuscitation·2024

Related Experiment Video

Updated: Jul 29, 2025

CMAP Scan MUNE MScan - A Novel Motor Unit Number Estimation MUNE Method
08:25

CMAP Scan MUNE MScan - A Novel Motor Unit Number Estimation MUNE Method

Published on: June 7, 2018

12.4K

Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres.

D M Sørensen1, H Bostock2, A Abrahao3

  • 1Department of Clinical Neurophysiology, Aarhus University Hospital, Denmark.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|May 26, 2023
PubMed
Summary

The MScanFit-2 program shows improved repeatability for motor unit number estimation (MUNE) in multicenter studies, especially for the tibialis anterior muscle, making it suitable for clinical research.

Keywords:
CMAP ScanMScanFitMUNEMotor unit number estimationRepeatability

More Related Videos

Electrophysiological Motor Unit Number Estimation MUNE Measuring Compound Muscle Action Potential CMAP in Mouse Hindlimb Muscles
09:07

Electrophysiological Motor Unit Number Estimation MUNE Measuring Compound Muscle Action Potential CMAP in Mouse Hindlimb Muscles

Published on: September 25, 2015

21.3K
Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases
06:08

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

Published on: April 19, 2024

452

Related Experiment Videos

Last Updated: Jul 29, 2025

CMAP Scan MUNE MScan - A Novel Motor Unit Number Estimation MUNE Method
08:25

CMAP Scan MUNE MScan - A Novel Motor Unit Number Estimation MUNE Method

Published on: June 7, 2018

12.4K
Electrophysiological Motor Unit Number Estimation MUNE Measuring Compound Muscle Action Potential CMAP in Mouse Hindlimb Muscles
09:07

Electrophysiological Motor Unit Number Estimation MUNE Measuring Compound Muscle Action Potential CMAP in Mouse Hindlimb Muscles

Published on: September 25, 2015

21.3K
Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases
06:08

Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases

Published on: April 19, 2024

452

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Clinical Electrophysiology

Background:

  • Motor Unit Number Estimation (MUNE) is crucial for assessing neuromuscular disorders.
  • MScanFit software models compound muscle action potential (CMAP) scans for MUNE.
  • Previous versions of MScanFit were optimized for patient scans with discontinuities.

Purpose of the Study:

  • To evaluate the repeatability and multicenter suitability of MScanFit for MUNE.
  • To compare the original MScanFit-1 with a revised MScanFit-2 program.
  • To assess MUNE performance across different muscles (APB, ADM, TA) and international research sites.

Main Methods:

  • Fifteen international research groups recorded CMAP scans from healthy subjects twice, 1-2 weeks apart.
  • MScanFit-1 and MScanFit-2 were used to analyze scans from abductor pollicis brevis (APB), abductor digiti minimi (ADM), and tibialis anterior (TA) muscles.
  • MScanFit-2 incorporated a revised method for setting minimal motor unit size based on maximum CMAP amplitude.

Main Results:

  • Significant inter-center variability in CMAP amplitudes and MScanFit-1 MUNE was observed.
  • MScanFit-2 reduced inter-center MUNE differences, though APB remained significantly different.
  • Repeatability coefficients of variation were 18.0% (ADM), 16.8% (APB), and 12.1% (TA).

Conclusions:

  • MScanFit-2 is recommended for multicenter MUNE studies.
  • The tibialis anterior muscle yielded the most repeatable and least variable MUNE values.
  • MScanFit's suitability for healthy subjects with smooth CMAP scans is enhanced by MScanFit-2.