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Activity recovery for differently shaped objects in quantitative SPECT.

Pablo Mínguez Gabiña1,2, Teresa Monserrat Fuertes3,4, Inés Jauregui5

  • 1Department of Medical Physics and Radiation Protection, Gurutzeta-Cruces University Hospital/ Biocruces Bizkaia Health Research Institute, Plaza Cruces s/n, E-48903 Barakaldo, Spain.

Physics in Medicine and Biology
|May 26, 2023
PubMed
Summary
This summary is machine-generated.

This study investigated Single-Photon Emission Computed Tomography (SPECT) image recovery across various object shapes. Signal Rate Per Activity (SRPA) analysis revealed shape-independent behavior when plotted against the volume-to-surface ratio, improving activity estimation accuracy.

Keywords:
3D-printingpartial-volume effectsquantitative SPECTrecovery

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Area of Science:

  • Nuclear Medicine
  • Medical Imaging Physics

Background:

  • Accurate quantification of radiotracer uptake in Single-Photon Emission Computed Tomography (SPECT) is crucial for effective diagnosis and treatment monitoring.
  • Object shape can influence image reconstruction and quantitative accuracy in SPECT imaging.
  • Standardized methods for assessing signal recovery across diverse geometries are needed to reduce uncertainties.

Purpose of the Study:

  • To theoretically and experimentally investigate SPECT image recovery in objects of varying shapes (spheres, oblate spheroids, prolate spheroids).
  • To evaluate the accuracy of volume estimation using thresholding methods for different object geometries.
  • To establish a shape-independent metric for activity quantification in SPECT.

Main Methods:

  • SPECT phantom inserts of spheres, oblate spheroids, and prolate spheroids were imaged using 99mTc and 177Lu on different gamma cameras.
  • Signal Rate Per Activity (SRPA) was determined and analyzed as a function of volume-to-surface ratio and volume-equivalent radius.
  • Experimental SRPA data were compared with analytical and numerical models, with validation using ellipsoidal phantoms.
  • Threshold values for accurate volume determination were identified.

Main Results:

  • Signal Rate Per Activity (SRPA) values diverged for oblate spheroids when plotted against volume-equivalent radius.
  • However, SRPA values for all investigated shapes (spheres, spheroids, ellipsoids) exhibited similar behavior when plotted against the volume-to-surface ratio.
  • Accurate volume estimation using thresholding was achieved for volumes exceeding 25 ml across all shapes.
  • Experimental findings aligned with theoretical models.

Conclusions:

  • Representing SPECT signal recovery as a function of the volume-to-surface ratio provides a shape-independent measure.
  • This shape-independent approach can decrease uncertainties in estimated SPECT activities.
  • Improved activity quantification accuracy holds long-term benefits for patient care in nuclear medicine.