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Fortunilides M-O, anti-inflammatory lindenane sesquiterpenoid dimers from Chloranthus fortunei
Siyuan Wang1, Yaqi Li1, Xiaoli Wang1
1Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Abstract:
Fortunilides M-O (1-3), three new lindenane-type sesquiterpenoid dimers, together with eighteen known dimers (4-21), were isolated from the roots of Chloranthus fortunei. The structures were determined by their NMR, HRESIMS, ECD data and quantum chemical calculations. All compounds were classical [4 + 2] lindenane-type sesquiterpenoid dimers, in which compounds 2-4 and 16-17 had rare additional carbon‑carbon link between C-11 and C-7'. Their anti-inflammatory activity in LPS-induced RAW 264.7 and BV2 microglial cells were screened, and compounds 9 (IC50: 10.70 ± 0.25 μM) and 2 (IC50: 12.26 ± 2.43 μM) showed significant effect, respectively.
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