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Importance of Magnesium Status in COVID-19
Fernando Guerrero-Romero1, Oliver Micke2, Luis E Simental-Mendía1
1Biomedical Research Unit, Mexican Social Security Institute, Durango 34067, Mexico.
Biology
|May 27, 2023
Summary
Magnesium (Mg) status may protect against severe COVID-19 outcomes. Maintaining adequate serum and dietary Mg levels, and exploring inhaled Mg, could be beneficial for patients with COVID-19.
Area of Science:
- Nutritional Immunology
- Infectious Diseases
- Mineral Metabolism
Background:
- Magnesium (Mg) is essential for cardiovascular, immunological, respiratory, and neurological functions.
- Low serum and dietary Mg are linked to increased COVID-19 severity and mortality.
- Populations with high COVID-19 mortality often consume Mg-deficient diets.
Purpose of the Study:
- To review existing research on the impact of magnesium status on COVID-19 outcomes.
- To explore the potential protective role of magnesium in COVID-19 disease course.
- To assess magnesium's role in COVID-19 associated neuropsychiatric complications.
Main Methods:
- Comprehensive review of published research on magnesium and COVID-19.
- Analysis of associations between magnesium levels, dietary intake, and COVID-19 severity.
- Evaluation of magnesium's physiological roles in relation to COVID-19 pathophysiology.
Main Results:
- Serum Mg levels between 2.19-2.26 mg/dL and dietary intake >329 mg/day may be protective.
- Inhaled magnesium shows potential for improving oxygenation in hypoxic COVID-19 patients.
- Magnesium deficiency is implicated in neuropsychiatric symptoms associated with COVID-19.
Conclusions:
- Magnesium status appears relevant for COVID-19 outcomes, with potential protective effects.
- Further clinical trials investigating oral magnesium supplementation for COVID-19 patients are warranted.
- Magnesium may play a role in mitigating drug side effects and enhancing therapy effectiveness.
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