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Related Experiment Videos

Fever induced by labetalol.

B H Stricker, H S Heijermans, H Braat

    JAMA
    |August 1, 1986
    PubMed
    Summary

    Fever from beta-adrenoceptor blocking agents is rare. Labetalol can cause rare, unpredictable fevers, likely due to an immunoallergic reaction, as seen in two patients.

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    Area of Science:

    • Pharmacology
    • Immunology
    • Adverse Drug Reactions

    Background:

    • Beta-adrenoceptor blocking agents are commonly prescribed.
    • Fever is a rare adverse effect associated with these medications.

    Observation:

    • Two patients developed fever during labetalol treatment.
    • Fever resolved upon labetalol discontinuation and recurred upon rechallenge.

    Findings:

    • The adverse effect exhibited a sensitization period of 3-4 weeks.
    • The reaction was dose-independent and showed accelerated rechallenge response.
    • Evidence suggests an immunoallergic mechanism for labetalol-induced fever.

    Implications:

    • Clinicians should consider labetalol-induced fever in patients presenting with unexplained fever.
    • This highlights the importance of recognizing rare immunoallergic drug reactions.
    • Further research into the specific immunological pathways is warranted.