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Multifunctional Biosensing Platform Based on Nickel-Modified Laser-Induced Graphene.

Yao Tong1,2, Yingying Zhang1,2, Benkun Bao2

  • 1School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.

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Nickel plating on laser-induced graphene (LIG) electrodes enhances conductivity and sensing capabilities. This LIG-Ni sensor can monitor physiological signals non-invasively, aiding in health monitoring and disease diagnosis.

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Area of Science:

  • Materials Science
  • Electrochemistry
  • Sensor Technology

Background:

  • Laser-induced graphene (LIG) offers a promising platform for electrochemical sensors.
  • Enhancing the conductivity and stability of LIG is crucial for practical applications.
  • Developing multi-functional sensors for continuous physiological monitoring is a key challenge.

Purpose of the Study:

  • To develop nickel-plated LIG (LIG-Ni) electrodes for enhanced sensing performance.
  • To investigate the potential of LIG-Ni for electrophysiological, strain, and electrochemical sensing.
  • To explore the application of LIG-Ni in non-invasive monitoring of multiple physiological parameters.

Main Methods:

  • Nickel plating of LIG electrodes using a simple salt solution.
  • Characterization of electrical, electrochemical, mechanical, wear, and corrosion properties of LIG-Ni.
  • Chemical modification of LIG-Ni for specific analyte detection (e.g., glucose, pH, Na+).
  • Validation of the sensor's performance in monitoring physiological signals like pulse and respiration.

Main Results:

  • Nickel plating significantly improved the conductivity, electrochemical properties, wear resistance, and corrosion resistance of LIG.
  • The LIG-Ni sensor demonstrated sensitivity to various deformations, enabling monitoring of pulse, respiration, and swallowing.
  • Chemically modified LIG-Ni exhibited strong catalytic effects for glucose sensing and potential for pH and Na+ monitoring.
  • The developed sensor showed continuous monitoring capabilities for multiple physiological parameters.

Conclusions:

  • Nickel-plated LIG electrodes are highly suitable for advanced sensing applications.
  • The LIG-Ni sensor platform enables non-invasive monitoring of multiple physiological parameters from sweat.
  • This technology holds significant promise for integrated multi-physiological sensor systems for health monitoring, disease prevention, and diagnosis.