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Correction: Coulter et al. OrgTRx: A Platform Developed in Queensland for the Extraction and Visualisation of Antimicrobial Susceptibility Data for the Surveillance of Resistance in Microorganisms. <i>Antibiotics</i> 2026, <i>15</i>, 63.

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Chlorhexidine Resistance or Cross-Resistance, That Is the Question.

Hadeel Mohammed Abbood1,2, Karolin Hijazi1, Ian M Gould3

  • 1Institute of Dentistry, School of Medicine, Medical Science and Nutrition, University of Aberdeen, Aberdeen AB25 2ZR, UK.

Antibiotics (Basel, Switzerland)
|May 27, 2023
PubMed
Summary
This summary is machine-generated.

Concerns exist regarding bacterial resistance to the biocide chlorohexidine (CHX), with potential cross-resistance to antibiotics. Further research is needed to understand CHX

Keywords:
antibiotic resistancebiocides (disinfectants)chlorhexidinecross-resistance

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Area of Science:

  • Microbiology
  • Antimicrobial Resistance
  • Public Health

Background:

  • Chlorohexidine (CHX) is a common biocide in healthcare and homes.
  • Bacterial resistance to CHX has been observed, sometimes at sub-clinical concentrations.
  • In vitro studies suggest CHX-adapted bacteria may develop cross-resistance to antibiotics.

Purpose of the Study:

  • To review the current understanding of CHX resistance and cross-resistance.
  • To highlight the need for standardized testing methods for CHX susceptibility.
  • To emphasize the potential impact of CHX use on the broader issue of antimicrobial resistance.

Main Methods:

  • Literature review of studies on CHX resistance and cross-resistance.
  • Analysis of findings from in vitro and observational studies.
  • Synthesis of evidence regarding resistance mechanisms and clinical implications.

Main Results:

  • CHX resistance is reported in various bacteria, often at low concentrations.
  • Cross-resistance between CHX and antibiotics is a documented phenomenon in vitro.
  • Inconsistent laboratory methods complicate the synthesis of resistance data.

Conclusions:

  • CHX resistance and cross-resistance warrant further investigation in clinical and environmental settings.
  • Standardized susceptibility testing for CHX is crucial for accurate assessment.
  • Healthcare provider awareness of CHX's potential role in antimicrobial resistance selection is recommended.