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Updated: Jul 29, 2025
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
Recent Advances in Pharmaceutical Approaches of Antimicrobial Agents for Selective Delivery in Various Administration
Ardiyah Nurul Fitri Marzaman1, Tri Puspita Roska1, Sartini Sartini1
1Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
Abstract:
Globally, the increase of pathogenic bacteria with antibiotic-resistant characteristics has become a critical challenge in medical treatment. The misuse of conventional antibiotics to treat an infectious disease often results in increased resistance and a scarcity of effective antimicrobials to be used in the future against the organisms. Here, we discuss the rise of antimicrobial resistance (AMR) and the need to combat it through the discovery of new synthetic or naturally occurring antibacterial compounds, as well as insights into the application of various drug delivery approaches delivered via various routes compared to conventional delivery systems. AMR-related infectious diseases are also discussed, as is the efficiency of various delivery systems. Future considerations in developing highly effective antimicrobial delivery devices to address antibiotic resistance are also presented here, especially on the smart delivery system of antibiotics.
Insights
Antimicrobial resistance (AMR) is a growing global threat. This study explores new antibacterial compounds and advanced drug delivery systems to combat resistant infections and improve treatment efficacy.
Area of Science:
- Microbiology
- Pharmacology
- Drug Delivery
Background:
- Rising antimicrobial resistance (AMR) poses a critical challenge to global health.
- Misuse of conventional antibiotics accelerates resistance, limiting future treatment options.
- Pathogenic bacteria are increasingly exhibiting antibiotic-resistant characteristics.
Purpose of the Study:
- To discuss the escalating issue of antimicrobial resistance (AMR).
- To explore novel antibacterial compounds (synthetic and natural) for combating AMR.
- To review advanced drug delivery systems as alternatives to conventional methods.
Main Methods:
- Literature review on antimicrobial resistance trends.
- Analysis of current and emerging antibacterial discovery approaches.
- Evaluation of various drug delivery systems and routes for antimicrobial agents.
Main Results:
- AMR necessitates the discovery of new antibacterial agents.
- Diverse drug delivery strategies show potential for enhanced antimicrobial efficacy.
- Conventional delivery systems face limitations against resistant pathogens.
Conclusions:
- Combating AMR requires a multi-faceted approach, including new drug discovery and innovative delivery systems.
- Advanced drug delivery, particularly smart systems, offers promising solutions for overcoming antibiotic resistance.
- Future research should focus on developing effective antimicrobial delivery devices.
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