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Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress.
Gideon Ong1, Susan E Logue1,2,3
1Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Antioxidants (Basel, Switzerland)
|May 27, 2023
Summary
Oxidative stress causes cellular damage and endoplasmic reticulum (ER) stress. This review explores how the unfolded protein response (UPR) network interacts with oxidative and ER stress, influencing antioxidant defenses.
Area of Science:
- Cellular Biology
- Biochemistry
- Molecular Biology
Background:
- Oxidative stress arises from reactive oxygen species (ROS) imbalance, impacting cellular functions.
- Excess ROS damages macromolecules and disrupts organelles like mitochondria and the endoplasmic reticulum (ER).
- ER stress, triggered by oxidative stress, leads to misfolded protein accumulation.
Purpose of the Study:
- To review the interplay between oxidative stress, ER stress, and unfolded protein response (UPR) signaling.
- To investigate how UPR mediators influence antioxidant responses.
Main Methods:
- Literature review of studies on oxidative stress, ER stress, and UPR.
- Analysis of signaling pathways connecting these stress responses.
Main Results:
- UPR signaling is a conserved cellular response to ER stress.
- The relationship between UPR mediators and oxidative stress is not fully understood.
- UPR signaling pathways can modulate cellular antioxidant capacities.
Conclusions:
- Understanding the UPR's role in oxidative stress is crucial for cellular health.
- UPR mediators offer potential targets for therapeutic interventions against oxidative damage.
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