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Updated: Jul 29, 2025

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Diabetic Nephropathy and Gaseous Modulators.

Subir Kumar Juin1,2, Rosemary Ouseph3, Dibson Dibe Gondim4

  • 1Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.

Antioxidants (Basel, Switzerland)
|May 27, 2023
PubMed
Summary
This summary is machine-generated.

Diabetic nephropathy (DN) involves altered gasotransmitters like nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). These molecules influence DN progression, offering potential therapeutic targets for kidney disease in diabetes.

Keywords:
carbon monoxidediabetic nephropathyhydrogen sulfidenitric oxide

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Area of Science:

  • Endocrinology and Metabolism
  • Nephrology
  • Biochemistry

Background:

  • Diabetic nephropathy (DN) is a major complication of diabetes, leading to end-stage renal disease (ESRD) despite current treatments.
  • The precise mechanisms driving DN progression remain incompletely understood.
  • Gasotransmitters (nitric oxide, carbon monoxide, hydrogen sulfide) are emerging as key players in metabolic and renal physiology.

Purpose of the Study:

  • To review the physiological roles of gasotransmitters in diabetic nephropathy.
  • To explore the interaction of gasotransmitters with factors like extracellular matrix (ECM) in DN.
  • To highlight potential therapeutic strategies involving gasotransmitters for DN.

Main Methods:

  • Literature review of recent advances in gasotransmitter research related to DN.
  • Analysis of studies investigating aberrant gasotransmitter levels in diabetes patients.
  • Examination of evidence for gasotransmitter donors in ameliorating diabetic renal dysfunction.

Main Results:

  • Gasotransmitters exhibit aberrant levels in diabetic patients, influencing DN development and progression.
  • Gasotransmitters interact with other factors, such as ECM, affecting DN severity.
  • Gasotransmitter donors have shown promise in improving diabetic renal dysfunction.

Conclusions:

  • Gasotransmitters play a critical, multifaceted role in the pathogenesis and modulation of diabetic nephropathy.
  • Understanding these roles opens avenues for novel therapeutic interventions targeting gasotransmitter pathways.
  • Further research into gasotransmitter-based therapies could significantly impact DN management and patient outcomes.