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Updated: Jul 29, 2025
08:41
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
1.2K
Spectral CT: Current Liver Applications.
Ana P Borges1,2,3, Célia Antunes1,3, Filipe Caseiro-Alves1,2,3
1Medical Imaging Department, Coimbra University Hospitals, 3004-561 Coimbra, Portugal.
Diagnostics (Basel, Switzerland)
|May 27, 2023
Summary
Dual-energy computed tomography (DECT) enhances liver disease diagnosis by improving lesion detection and characterization. Challenges like image quality in larger patients exist, but new techniques promise better results with lower radiation doses.
Area of Science:
- Radiology
- Medical Imaging
- Hepatology
Background:
- Dual-energy computed tomography (DECT) utilizes two different energy levels for enhanced material differentiation.
- DECT improves image quality, iodine conspicuity, and enables iodine contrast assessment and radiation dose reduction.
- DECT platforms and clinical applications are continuously evolving across various diseases.
Purpose of the Study:
- To review the current applications of DECT in liver disease treatment.
- To identify the challenges associated with DECT use in managing liver conditions.
Main Methods:
- Review of current literature on DECT applications in liver diseases.
- Analysis of DECT capabilities including material differentiation, iodine quantification, and fat/iron/fibrosis assessment.
Main Results:
- DECT's low-energy images and iodine quantification are valuable for lesion detection, characterization, staging, treatment response assessment, and thrombi characterization.
- Material decomposition techniques allow non-invasive quantification of fat, iron, and fibrosis.
- Limitations include reduced image quality in larger body sizes, scanner variability, and long reconstruction times.
Conclusions:
- DECT offers significant advantages in diagnosing and managing liver diseases.
- Emerging techniques like deep learning reconstruction and photon-counting CT show promise for overcoming DECT limitations and reducing radiation dose.
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