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Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study
Camilla Astley1,2, Gabriela Nunes Leal3, Saulo Gil1
1Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, University of Sao Paulo, Sao Paulo 01246-903, Brazil.
Insights
Exercise may improve recovery for children with multisystemic inflammatory syndrome (MIS-C). Patients who exercised showed better quality of life, cardiac function, and fitness compared to those who did not.
Area of Science:
- Pediatric Cardiology
- Cardiovascular Health
- Rehabilitation Medicine
Background:
- Multisystemic inflammatory syndrome in children (MIS-C) can impact long-term health.
- Understanding the recovery process and therapeutic interventions for MIS-C survivors is crucial.
Purpose of the Study:
- To evaluate the therapeutic potential of exercise in improving health-related quality of life, cardiac function, and fitness in pediatric patients post-MIS-C.
Main Methods:
- A 12-week home-based exercise intervention was studied in children and adolescents following MIS-C.
- Outcomes included health-related quality of life (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and blood markers.
Main Results:
- Patients who exercised demonstrated improvements in quality of life, CFR, cardiac function, and aerobic conditioning.
- Non-exercised patients showed a slower recovery trajectory, particularly in quality of life and aerobic fitness.
Conclusions:
- Exercise appears to have a beneficial therapeutic role for post-discharge MIS-C patients.
- Further randomized controlled trials are needed to establish causality and confirm these findings.
Objective:
To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisystemic inflammatory syndrome in children (MIS-C) patients.
Methods:
This is a case series study of a 12-wk, home-based exercise intervention in children and adolescents after MIS-C diagnosis. From 16 MIS-C patients followed at our clinic, 6 were included (age: 7-16 years; 3 females). Three of them withdrew before the intervention and served as controls. The primary outcome was health-related quality of life, assessed PODCI. Secondary outcomes were CFR assessed by 13N-ammonia PET-CT imaging, cardiac function by echocardiography, cardiorespiratory fitness, and inflammatory and cardiac blood markers.
Results:
In general, patients showed poor health-related quality of life, which seemed to be improved with exercise. Additionally, exercised patients showed improvements in coronary flow reserve, cardiac function, and aerobic conditioning. Non-exercised patients exhibited a slower pattern of recovery, particularly in relation to health-related quality of life and aerobic conditioning.
Conclusions:
Our results suggest that exercise may play a therapeutic role in the treatment of post-discharge MIS-C patients. As our design does not allow inferring causality, randomized controlled trials are necessary to confirm these preliminary findings.
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