Translating Precision Health for Pediatrics: A Scoping Review

Area of Science:

• Pediatric precision health
• Translational science
• Evidence-based medicine

Background:

• Precision health personalizes care using genetic differences, improving outcomes for some groups.
• Broader implementation faces hurdles in evidence development, appraisal, and integration.
• Existing methods often neglect the unique physiology and socio-biology of children.

Purpose of the Study:

• To review and synthesize literature on evidence development, appraisal, prioritization, and implementation of precision child health.
• To identify challenges and solutions for translating precision health into pediatric practice.
• To highlight the unique considerations for children in precision health research.

Main Methods:

• Scoping review of literature.
• Searches conducted in PubMed, Scopus, Web of Science, and Embase.
• Inclusion criteria focused on pediatrics, precision health, and translational pathways.

Main Results:

• 74 articles identified challenges and solutions for pediatric precision health interventions.
• Unique attributes of children significantly impact study design.
• Key themes for value assessment include clinical benefit, cost-effectiveness, stakeholder values, and ethics.

Conclusions:

• Addressing challenges requires international data networks and guidelines.
• Rethinking value assessment methods is crucial.
• Broadening stakeholder support is essential for effective implementation of precision child health.